Mycobacterium abscessus disease candidate vaccine protein as well as preparation method and application thereof

The invention provides a mycobacterium abscessus disease candidate vaccine protein, a preparation method and application, and belongs to the technical field of mycobacterium abscessus disease vaccines. The amino acid sequence of the candidate vaccine protein for the mycobacterium abscessus disease i...

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Hauptverfasser: KONG YAOYAO, YU XIA, HUANG HAIRONG, WU JING, GU YUZHEN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a mycobacterium abscessus disease candidate vaccine protein, a preparation method and application, and belongs to the technical field of mycobacterium abscessus disease vaccines. The amino acid sequence of the candidate vaccine protein for the mycobacterium abscessus disease is as shown in SEQ ID No. 1. The mycobacterium abscessus disease candidate vaccine protein MAB2734c provided by the invention can stimulate host cells to generate specific immune response reaction, and when MAB2734c target genes exist in mycobacterium abscessus, TLR2 and TLR4 receptors can be activated, so that the release amount of proinflammatory factors TNF-alpha, IL-6 and IL-1beta is increased, and the release amount of the proinflammatory factors is increased along with the increase of protein concentration; therefore, the protein can be used as a candidate protein of a mycobacterium abscessus vaccine. 本发明提供一种脓肿分枝杆菌病候选疫苗蛋白、制备方法及应用,属于脓肿分枝杆菌病疫苗技术领域。所述脓肿分枝杆菌病候选疫苗蛋白的氨基酸序列如SEQ ID No.1所示。本发明所提供的脓肿分枝杆菌病候选疫苗蛋白MAB_2734c