Cerium oxide-zirconium oxide and arginine nano-composite medicine for targeting arterial vulnerable plaque microenvironment as well as preparation and application of cerium oxide-zirconium oxide and arginine nano-composite medicine

The invention provides a cerium oxide-zirconium oxide and arginine nano composite drug targeting an arterial vulnerable plaque microenvironment as well as preparation and application thereof. The cerium oxide-zirconium oxide and arginine nano composite drug comprises L-arginine, solid cerium oxide-zirconium oxide nano enzyme, osteopontin oligopeptide and a liposome carrier. Wherein the mass ratio of the L-arginine to the solid cerium oxide-zirconium oxide nano-enzyme to the osteopontin oligopeptide is 2: 5: 2, and the mass ratio of the liposome carrier to the sum of the three substances is 1: 1600-1800. The ceria-zirconia nano enzyme and alkaline L-arginine are encapsulated by innovatively utilizing a sustained release preparation technology, a plaque microenvironment is neutralized, and meanwhile, the surface modified osteopontin can release drugs in a targeted manner, so that specific treatment on foam cells is realized. The compound disclosed by the invention realizes anti-aging treatment of atherosclerosi