Application of wedelolactone analogue as novel topoisomerase I toxic agent

The invention discloses application of wedelolactone derivatives I-IV or pharmaceutically acceptable salts of the wedelolactone derivatives I-IV in a topoisomerase I inhibitor and tumor treatment. Wedelolactone derivatives I-IV have an excellent inhibition effect on topoisomerase I, the activity of a compound III is close to that of camptothecin, and the compound III is a Top1 toxic agent; the wedelolactone derivatives I-IV have very strong anti-tumor activity, and effectively inhibit proliferation of tumor cells. 本发明公开了一种蟛蜞菊内酯衍生物I-IV或其药学上可接受的盐在拓扑异构酶I抑制剂和治疗肿瘤中的应用。蟛蜞菊内酯衍生物I-IV对拓朴异构酶I有优秀的抑制作用，化合物III的活性接近喜树碱，是一类Top1毒剂；蟛蜞菊内酯衍生物I-IV具有很强的抗肿瘤活性，有效抑制肿瘤细胞的增值。