Compositions and methods for ribonucleic acid respiratory syncytial virus (RSV) vaccines

Provided herein is a ribonucleic acid (RNA) encoding a fusion glycoprotein (F) protein of respiratory syncytial virus (RSV) or an immunogenic fragment thereof, the F protein or immunogenic fragment thereof comprising at least one non-naturally occurring amino acid mutation. Related polynucleotides,...

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Bibliographische Detailangaben
Hauptverfasser:	ANANTHASWAMY NITHSH, BROWN DAVID, CHEN RENXIANG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein is a ribonucleic acid (RNA) encoding a fusion glycoprotein (F) protein of respiratory syncytial virus (RSV) or an immunogenic fragment thereof, the F protein or immunogenic fragment thereof comprising at least one non-naturally occurring amino acid mutation. Related polynucleotides, vectors, cells, compositions, kits, methods of production, and methods of use are also provided. 本文提供了编码呼吸道合胞病毒(RSV)的融合糖蛋白(F)蛋白或其免疫原性片段的核糖核酸(RNA)，该F蛋白或其免疫原性片段包含至少一个非天然存在的氨基酸突变。另外提供了相关的多核苷酸、载体、细胞、组合物、试剂盒、生产方法和使用方法。