Method for synthesizing oxime containing imidazole group and method for synthesizing nitrile oxide from oxime

The invention relates to a novel process for the synthesis of a compound of formula (I) as defined in claim 1, comprising the following consecutive steps A1, A2, A3: Step A1: obtaining an intermediate compound of formula (V) by a halomethylation reaction of an aromatic aldehyde of formula (VI) in th...

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Hauptverfasser: RUHL, PETER, IVANOV SERGEY, JOSEPH JOHN C, JEAN-BAPTISTE-DIT-DOMINIQUE FRANCOIS, UGOLNIKOV OLEG, MICHAUX JULIEN, LEROUX SAMUEL
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a novel process for the synthesis of a compound of formula (I) as defined in claim 1, comprising the following consecutive steps A1, A2, A3: Step A1: obtaining an intermediate compound of formula (V) by a halomethylation reaction of an aromatic aldehyde of formula (VI) in the presence of a halomethylation reagent according to the reaction scheme according to claim 1; a2, according to the reaction scheme in claim 1, carrying out nucleophilic substitution on the intermediate compound of the formula (V) and an imidazole compound of a formula (IV) to obtain an intermediate compound of a formula (III); step A3, according to the reaction scheme in the claim 1, carrying out condensation reaction on the intermediate compound of the formula (III) and hydroxylamine (II) to obtain a compound of a formula (I); steps A1, A2, A3 are carried out without separating at least one intermediate compound selected from the group consisting of the intermediate compounds of formula (III) and the intermediate