Anti-tumor polypeptide capable of targeting and degrading BRD4 and simultaneously interfering interaction of JMJD6-BRD4 and application of anti-tumor polypeptide

The invention discloses an anti-tumor polypeptide capable of targeting and degrading BRD4 and simultaneously interfering interaction of JMJD6-BRD4 and application of the anti-tumor polypeptide. The invention belongs to the technical field of biological medicines, and mainly relates to an anti-tumor polypeptide comprising a TAT-P3-PROTAC polypeptide and application of the anti-tumor polypeptide in preparation of an inhibitor or a medicine. The P3 sequence, the transmembrane sequence and the PROTAC modification sequence of the TAT-P3-PROTAC polypeptide provided by the invention are as shown in SEQ ID No. 1 to SEQ ID No. 3. The P3 polypeptide can effectively and specifically bind to the ET structural domain of BRD4 and simultaneously interfere the interaction of JMJD6-BRD4, the binding constant Kd value of P3 is 194 [mu] M, the P3 polypeptide has transmembrane sequences TAT and PROTAC sequences and can achieve the technical effect of inhibiting cancer cell proliferation, and meanwhile, the PROTAC sequences have