Lipid-lowering polypeptide and application thereof

The invention provides a lipid-lowering polypeptide PEP-IPA. The amino acid sequence of the polypeptide is as shown in SEQ ID NO: 1. The polypeptide PEP-IPA provided by the invention aims at a PCSK9 protein target spot, shows a good effect in an in-vivo and in-vitro experiment for inhibiting PCSK9,...

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Bibliographische Detailangaben
Hauptverfasser:	SHI SONGCHUAN, ZHAO SHUMIN, CAMPBELL WILLIAM
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides a lipid-lowering polypeptide PEP-IPA. The amino acid sequence of the polypeptide is as shown in SEQ ID NO: 1. The polypeptide PEP-IPA provided by the invention aims at a PCSK9 protein target spot, shows a good effect in an in-vivo and in-vitro experiment for inhibiting PCSK9, and can be used for preparing medicines for treating cardiovascular diseases, hyperlipidemia, mixed dyslipidemia and hypercholesterolemia. 本申请提供一种降脂多肽PEP-IPA，所述多肽的氨基酸序列如SEQ ID NO：1所示。本申请所述多肽PEP-IPA针对PCSK9蛋白靶点，在抑制PCSK9的体内体外实验中显示良好的效果，可用于制备治疗如心血管疾病、高血脂症、混合性血脂异常和高胆固醇血症的药物。