Engineered exosome for treating sepsis lung injury as well as preparation method and application of engineered exosome

The invention belongs to the field of biological materials, and particularly relates to an engineered exosome for treating sepsis lung injury as well as a preparation method and application of the engineered exosome. The engineered exosome for treating sepsis lung injury provided by the invention comprises an active component, a targeting part and an antioxidant part, the active component comprises a drug-loaded exosome loaded with antibacterial peptide MDC through electroporation; the targeting part comprises a targeting peptide compound DSPE-PEG (Polyethylene Glycol)-gamma 3; the antioxidant part comprises cerium dioxide nano particles CeO2 wrapped by DSPE-PEG-SH (Distearoyl Sulfonate Polyethylene-Polyethylene Glycol) and PDA (Polydopamine). The invention provides the engineered exosome MDC (at) Ex-gamma3-CeO2 (at) PDA capable of performing targeted therapy on the sepsis lung injury, and the engineered exosome has remarkable anti-inflammatory and anti-oxidative injury effects. 本发明属于生物材料领域，具体涉及用于脓毒症肺损伤治疗的工程化