Composite vaccine adjuvant as well as preparation method and application thereof

The invention belongs to the technical field of vaccine adjuvants, and particularly relates to a composite vaccine adjuvant and a preparation method and application thereof.The composite vaccine adjuvant comprises an aluminum metal organic framework, an oil-in-water emulsion and a hydrophilic polymer, the preparation method comprises the following steps that S1, the aluminum metal organic framework is prepared and modified; s2, preparing an aluminum metal organic framework-oil-in-water emulsion composite nano adjuvant, S3, preparing a hydrophilic polymer-stabilized aluminum metal organic framework-oil-in-water emulsion composite nano adjuvant preparation, mixing the sterilized composite nano adjuvant and an animal immunizing antigen according to a volume ratio of 1: 5 to prepare the vaccine, the adjuvant and the vaccine have good stability and safety, and can be used for preparing the animal immunizing antigen vaccine. The immune effect of the vaccine can be effectively enhanced, the preparation process is si