Aerosol inhalation solution for slowly releasing arformoterol tartrate as well as preparation method and application of aerosol inhalation solution

The invention belongs to the technical field of medicines, and particularly relates to a sustained-release arformoterol tartrate aerosol inhalation solution as well as a preparation method and application thereof. The preparation method of the slow-release arformoterol tartrate aerosol inhalation so...

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Hauptverfasser: XU ZHAO, CHEN XINGXING, JIANG LUOYIN, LU XIAOJUAN, CHEN HUIJUAN, LIU RONG, GAO HONG, ZHANG QIAN, WANG SONG, JIANG ZHIJUN
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention belongs to the technical field of medicines, and particularly relates to a sustained-release arformoterol tartrate aerosol inhalation solution as well as a preparation method and application thereof. The preparation method of the slow-release arformoterol tartrate aerosol inhalation solution comprises the following steps: preparing the nano-carrier loaded with arformoterol tartrate, then dissolving the nano-carrier loaded with arformoterol tartrate and the stabilizer in water for injection to obtain a mixed solution, adding the latent solvent, the osmotic pressure regulator and the pH regulator into the mixed solution, and uniformly stirring to obtain the slow-release arformoterol tartrate aerosol inhalation solution. And carrying out constant volume and split charging to obtain the sustained-release arformoterol tartrate aerosol inhalation solution. The nano-carrier disclosed by the invention and arformoterol tartrate can form a compound with electrostatic or hydrogen-bond interaction, so that