Combination therapy of KRAS G12D inhibitors with SHP-2 inhibitors

The present invention relates to a combination therapy for the treatment of KRas G12D cancer. Specifically, the present invention relates to a method of treating cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a combination of an SHP-2 inhibitor and a KRAS G12D inhibitor of formula (I), pharmaceutical compositions comprising a therapeutically effective amount of the inhibitor, kits comprising the compositions, and methods of use thereof. 本发明涉及用于治疗KRas G12D癌症的组合疗法。具体地，本发明涉及治疗有需要的受试者中的癌症的方法，所述方法包括向所述受试者施用治疗有效量的SHP-2抑制剂与式(I)的KRAS G12D抑制剂的组合，包含治疗有效量的所述抑制剂的药物组合物、包括所述组合物的药盒及其使用方法。