Fluorescently-labeled captopril and application thereof

The invention discloses fluorescently-labeled captopril and application thereof, and belongs to the technical field of medicines. The invention discloses a structural formula of fluorescently-labeled captopril and application of the captopril in preparation of a medicine for treating radiation-induc...

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Hauptverfasser: MA LIXIN, GAO YAN, XIA CHENGCHENG, CHEN KEXIN, XU XINGGUO, XIN YUNING, DONG LIHUA, WANG QIANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses fluorescently-labeled captopril and application thereof, and belongs to the technical field of medicines. The invention discloses a structural formula of fluorescently-labeled captopril and application of the captopril in preparation of a medicine for treating radiation-induced lung injury. According to the application, the captopril is chemically modified and combined with fluorescein isothiocyanate, so that the intracellular distribution of the radiation-induced lung injury medicine can be traced while the medicine effect is not influenced. Through administration treatment on alveolar epithelial cells, epithelial-mesenchymal transition after irradiation can be inhibited, and extracellular matrix deposition is reduced. Animal experiments show that the Cap is administered to mice through intragastric administration from the same day after irradiation, after continuous administration for 30 days, lung inflammation and lung collagen deposition can be obviously inhibited, and the progress