Indazole ether compound as well as preparation method and application thereof

The invention relates to the technical field of novel compounds, and particularly discloses an indazole ether derivative as well as a preparation method and application thereof. The invention provides an indazole ether derivative with a novel structure, an indazole group with good activity is used a...

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Bibliographische Detailangaben
Hauptverfasser: LI HONG, WU HAIXIA, XING YUXUAN, ZHANG ZHIGUANG, WANG HUIMING, ZHU ZHONGYANG, ZHAI PENGDA, GAO JINLONG, MA KAILE, XIA LIJIA, WANG YONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the technical field of novel compounds, and particularly discloses an indazole ether derivative as well as a preparation method and application thereof. The invention provides an indazole ether derivative with a novel structure, an indazole group with good activity is used as a parent nucleus structure, active groups such as N-methylpyridone, an amide group and a specific fluorine-containing functional group are introduced to a side chain of the indazole group, and the biological activity of the compound is effectively improved, so that the indazole ether derivative has a good application prospect. The invention not only enriches the types of the indazole ether compounds, but also provides a new compound for developing a novel glucocorticoid receptor modulator, and has very important significance for researching the activity of the indazole ether compounds and expanding the application of the compounds in drug synthesis. And a basis is provided for researching the glucocorticoid recep