Synthesis method of 2-mercaptopyridine

The invention relates to the technical field of synthesis of 2-mercaptopyridine, and particularly discloses a synthesis method of 2-mercaptopyridine, which comprises the following specific steps: step 1, dissolving 2-chloropyridine in a certain amount of solvent; 2, introducing the solution obtained...

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Bibliographische Detailangaben
Hauptverfasser: DU HUIQI, BAI YU, ZHU JING, MEN RONGTENG, XU JIAKANG, CAI DANDAN
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to the technical field of synthesis of 2-mercaptopyridine, and particularly discloses a synthesis method of 2-mercaptopyridine, which comprises the following specific steps: step 1, dissolving 2-chloropyridine in a certain amount of solvent; 2, introducing the solution obtained in the step 1 into the micro-channel reactor, and introducing a sulfo reagent at the same time; 3, after the reaction is completed, quantitative concentration is conducted, and then cooling crystallization is conducted; and 4, dissolving the crude product in a quantitative solvent, heating to 25-75 DEG C, stirring to a dissolved clear state, then adding an adsorbent, carrying out heat preservation adsorption, filtering, cooling the filtrate to 0-15 DEG C, stirring for crystallization, and after crystallization is completed, filtering, washing and drying to obtain a finished product. According to the method, the vulcanizing reagent with higher activity is adopted, the microchannel continuous flow reaction is used,