Injectable micro-nano composite microsphere with sequential controlled release function as well as preparation and application of injectable micro-nano composite microsphere

The invention discloses an injectable micro-nano composite microsphere with a sequential controlled release function as well as preparation and application of the injectable micro-nano composite microsphere. A main body scaffold material of the injectable micro-nano composite microsphere (SDF-1/PLGA-ECM MS) is a decellularized extracellular matrix (dECM), PLGA is used as an auxiliary material and adsorbs cytokines IL-4 and SDF-1, and the injectable micro-nano composite microsphere can be used for preparing the injectable micro-nano composite microsphere through compounding of a micro-nano structure and different degradation speeds of the decellularized extracellular matrix and the PLGA. The sequential release of cell factors IL-4 and SDF-1 is realized, so that the local inflammation after tissue defect can be improved, and the regeneration and repair of the defect tissue can be promoted. 本发明公开了一种具有时序控释功能的可注射微纳复合微球及其制备与应用。本发明的可注射微纳复合微球（SDF-1/PLGA-ECM MS）的主体支架材料是脱细胞细胞外基质（dECM），其中，PLGA作为辅助材料，以及吸附有细胞因子IL-4和SDF-1，