Method for preparing polyinosinic-polylysine mixed solution

The invention discloses a method for preparing a polyinosinic-polylysine mixed solution, and relates to the technical field of biology, in which sodium chloride with a relatively high concentration improves the ionic strength of a first mixed solution and a second mixed solution; the concentration o...

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Bibliographische Detailangaben
Hauptverfasser: LI FEI, LI GUOHUI, LIU ZONGZHU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a method for preparing a polyinosinic-polylysine mixed solution, and relates to the technical field of biology, in which sodium chloride with a relatively high concentration improves the ionic strength of a first mixed solution and a second mixed solution; the concentration of sodium ions around phosphate groups with negative charges on the polyinosinic acid in the first mixed solution and the polycytidylic acid in the second mixed solution is improved, the electrostatic repulsion between the polyinosinic acid and the polycytidylic acid is reduced, and the strength of hydrogen bond bonding between basic groups of the polyinosinic acid and the polycytidylic acid is promoted; the compactness of double helixes formed by the polyinosinic acid and the polycytidylic acid is increased; the polylysine has more positive charges than sodium ions, has weaker hydration capability and stronger electrostatic attraction with phosphate groups, and replaces part of sodium ions around the phosphate grou