Novel compounds for degrading target protein or polypeptide by multiplex ubiquitination

The present invention relates to a compound capable of degrading a target protein using ubiquitin, and provides a compound having a target protein binding moiety (TBM) structure that binds to a target protein or polypeptide, and an ubiquitin binding moiety (UBM) structure to which ubiquitin binds. The ubiquitin binding moiety structure present in the compounds can induce multiplex ubiquitination of the compounds of the invention, thereby having the benefit of becoming a protein degradation agent capable of degrading a target protein or polypeptide. 本发明有关于一种能够使用泛素降解靶蛋白的化合物，且提供具有靶蛋白结合部分(TBM)结构和泛素结合部分(UBM)结构的化合物，靶蛋白结合部分结构结合靶蛋白或多肽，泛素结合至泛素结合部分结构。化合物中存在的泛素结合部分结构可诱导本发明的化合物多重泛素化，从而具有成为能够降解靶蛋白或多肽的蛋白降解剂的益处。