Preparation method of 3-methylene (benzyl) piperidine

According to the preparation method of the 3-methylene (benzyl) piperidine, sodium tungstate is taken as a catalyst, hydrogen peroxide is taken as an oxidizing agent, an oxidized product can be obtained under a mild condition by cooperating with a micro-channel method, and then the oxidized product is further coupled with electron-deficient substituent groups such as p-toluenesulfonyl to prepare electron-deficient 3-methylene (benzyl) azetidine. And finally reacting with olefin under the catalytic action of silver nitrate to obtain the 3-methylene (benzyl) piperidine derivative. The method is relatively simple in process, mild in reaction condition, high in product quality, low in purification cost, low in equipment investment and safe in production operation, and meets the requirements of large-scale industrial production. 本发明一种3-亚甲(苄)基哌啶的制备方法，以钨酸钠为催化剂，双氧水为氧化剂，协同微通道法可以在温和的条件下得到氧化产品，再进一步和对甲苯磺基等缺电子型取代基偶联制备缺电子基型3-亚甲(苄)基氮杂环丁烷，最后在硝酸银的催化作用下和烯烃反应，即得到3-亚甲(苄)基哌啶衍生物。本发明工序相对简单，反应条件温和，产品品质高，纯化成本低，设备投入少，生产操作安全，符合大规模工业生产的