Crosslinked sodium hyaluronate gel and preparation method thereof

The invention relates to cross-linked sodium hyaluronate gel and a preparation method thereof, and relates to the technical field of biomaterials.The preparation method comprises the following steps that an alkaline solution and a cross-linking agent are mixed, then sodium hyaluronate is added, stirring and filtering are conducted, and first gel is obtained; pressing the first gel into a thin pancake shape, and then carrying out water bath crosslinking to obtain second gel; shearing the second gel into gel particles, adding the gel particles into a phosphate buffer solution for swelling, and purifying to obtain third gel; performing granulation and dehydration on the third gel to obtain fourth gel; and mixing the fourth gel with an additive, and standing to obtain the cross-linked sodium hyaluronate gel. By adding the free sodium hyaluronate and controlling condition parameters such as the adding proportion of the cross-linking agent and the like, the problems of poor subcutaneous lubricity, poor action effec