Modified MRNA vaccine encoding herpes simplex virus glycoprotein and use thereof

The present invention provides compositions for the prevention and treatment of genital herpes comprising nucleoside modified mRNA encoding a herpes simplex virus (HSV) glycoprotein, including mRNA involved in viral entry and immune escape, and methods of use thereof. 本发明提供了用于预防和治疗生殖器疱疹的组合物，其包含编码单纯疱...

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Bibliographische Detailangaben
Hauptverfasser:	AWASTHI, SRIKANTH, FRIEDMANN, HARRY, WEISSMANN DINAH, COHEN GUY
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides compositions for the prevention and treatment of genital herpes comprising nucleoside modified mRNA encoding a herpes simplex virus (HSV) glycoprotein, including mRNA involved in viral entry and immune escape, and methods of use thereof. 本发明提供了用于预防和治疗生殖器疱疹的组合物，其包含编码单纯疱疹病毒(HSV)糖蛋白的核苷修饰的mRNA，包括参与病毒进入和免疫逃逸的mRNA，及其使用方法。