Pharmaceutical formulations of anti-HLA-DQ2.5 antibodies

The invention relates to an anti-HLA-DQ2.5 antibody and a preparation containing the antibody. The present invention provides a modified anti-HLA-DQ2.5 (human leukocyte anti-DQ2.5) antibody. The anti-HLA-DQ2.5 antibody of the present invention has a binding activity against a complex formed by HLA-D...

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Bibliographische Detailangaben
Hauptverfasser:	EGAMI KIICHI, ARAI KENGO, FUKUDA MASAKAZU, HIRAYAMA KAZUNORI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY ENZYMOLOGY HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA HUMAN NECESSITIES HYGIENE INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to an anti-HLA-DQ2.5 antibody and a preparation containing the antibody. The present invention provides a modified anti-HLA-DQ2.5 (human leukocyte anti-DQ2.5) antibody. The anti-HLA-DQ2.5 antibody of the present invention has a binding activity against a complex formed by HLA-DQ2.5 and a glutelin peptide, but does not substantially have a binding activity against a complex formed by HLA-DQ2.5 and a non-related peptide. In addition, the antibody of the present invention exhibits an inhibitory effect on T cell activation via glutelin peptide. The invention also relates to a preparation containing the anti-HLA-DQ2.5 antibody, in particular a preparation for injection. 本发明涉及抗HLA-DQ2.5抗体和含有该抗体的制剂。本发明提供了经修饰的抗HLA-DQ2.5抗体。本发明的抗HLA-DQ2.5抗体对由HLA-DQ2.5和谷蛋白肽形成的复合物具有结合活性，但对由HLA-DQ2.5和非相关肽形成的复合物实质上不具有结合活性。此外，本发明的抗体显示出对经由谷蛋白肽的T细胞活化具有抑制作用。本发明还涉及含有抗HLA-DQ2.5抗体的制剂，特别是注射用制剂。