CAR (chimeric antigen receptor) molecule, cell or exosome containing CAR molecule and application of CAR molecule and cell or exosome

The invention discloses a CAR (chimeric antigen receptor) molecule, a cell or an exosome containing the CAR molecule and application of the CAR molecule and the cell or the exosome. The CAR molecule is a CAR molecule targeting at CD19 and/or a CAR molecule targeting at CD22. The invention also discloses a nucleic acid encoding the CAR molecule, a recombinant expression vector comprising the nucleic acid, and a pharmaceutical composition comprising the CAR molecule, a cell or an exosome comprising the CAR molecule. The CAR-T cell containing the CAR molecule provided by the invention has higher treatment effectiveness and treatment safety in clinical treatment; the exosome provided by the invention has better targeting property, can better realize tumor penetration, and is expected to become a new direction for treating tumors by CAR-T cell therapy. 本发明公开了一种CAR分子、包含其的细胞或外泌体及它们的应用。所述CAR分子为靶向CD19的CAR分子和/或靶向CD22的CAR分子。本发明还公开了编码所述CAR分子的核酸、包含所述核酸的重组表达载体和包含所述CAR分子、包含其的细胞或外泌体的药物组合物。本发明提供的包含所述CAR分子CAR-T细胞在临床治疗中的治疗有效性和治