Quadrivalent cis-platinum prodrug as well as liposome and application thereof

The invention relates to a tetravalent cisplatin prodrug as well as a liposome and application thereof. The tetravalent cisplatin prodrug has a structural formula as shown in a formula I, according to the tetravalent cisplatin prodrug liposome prepared from the tetravalent cisplatin prodrug disclose...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	HU HAIYANG, CHEN DAWEI, LI TAORAN, SONG YEHUI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEDICAL OR VETERINARY SCIENCE METALLURGY NANOTECHNOLOGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES TRANSPORTING
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention relates to a tetravalent cisplatin prodrug as well as a liposome and application thereof. The tetravalent cisplatin prodrug has a structural formula as shown in a formula I, according to the tetravalent cisplatin prodrug liposome prepared from the tetravalent cisplatin prodrug disclosed by the invention, the anti-tumor activity is remarkably improved, and the toxicity is reduced. And the prepared liposome has the advantages of high drug loading capacity and stability, simple preparation process and industrial application value. # imgabs0 # 本申请涉及一种四价顺铂前药及其脂质体与应用，该四价顺铂前药具有式I的结构式。以本申请的四价顺铂前药所制备的四价顺铂前药脂质体既显著提高了抗肿瘤活性，又降低了毒性。而且所制备的脂质体载药量和稳定性均较高，其制备工艺简单，具有产业化应用的价值。#imgabs0#