Application of OTUB1 in regulation of loratinib treatment sensitivity of non-small cell lung cancer

The invention discloses an application of OTUB1 in regulation of loratinib treatment sensitivity of non-small cell lung cancer, and provides an application of an inhibitor of a marker in preparation of a pharmaceutical composition for treating and/or preventing loratinib drug resistance of individua...

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Bibliographische Detailangaben
Hauptverfasser:	WU ZHENHAI, JIANG HAO, RAO YUANQUAN, HU HAIPING, CHEN BANGFEI, WU ZHIBING, LAN FUJUN, PENG GUANGCAI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses an application of OTUB1 in regulation of loratinib treatment sensitivity of non-small cell lung cancer, and provides an application of an inhibitor of a marker in preparation of a pharmaceutical composition for treating and/or preventing loratinib drug resistance of individual non-small cell lung cancer. The invention also provides a pharmaceutical composition for treating and/or preventing the Labotinib drug resistance of the individual non-small cell lung cancer, and also provides a method for screening candidate drugs for adjuvant treatment of the Labotinib drug resistance of the non-small cell lung cancer and application of the candidate drugs. The invention also provides a method for promoting ferroptosis and lipid peroxidation of non-small cell lung cancer loratinib drug-resistant cells or tissues with a non-treatment purpose in vitro and an application of the method. The invention provides an application and a method of the marker or the enhancer thereof in preparation of a prod