New application of Chinese pulsatilla root decoction in synergistic antibacterial effect of antibiotics

The invention relates to a new application of Chinese pulsatilla root decoction in enhancing antibacterial effects of ceftriaxone, tetracycline and amikacin antibiotics. When the composition or the compound preparation is prepared, the dosage ratio of the Chinese pulsatilla root decoction to the cef...

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Bibliographische Detailangaben
Hauptverfasser: CHEN YIHENG, DONG YING, LI YONGWEI, LIU LANPING, XIE MIAO, LIU BAOGUANG, PANG XIN, LIU YALIN, XU ERPING, JANG JONG-YOON, YUAN XIAOLING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a new application of Chinese pulsatilla root decoction in enhancing antibacterial effects of ceftriaxone, tetracycline and amikacin antibiotics. When the composition or the compound preparation is prepared, the dosage ratio of the Chinese pulsatilla root decoction to the ceftriaxone, the tetracycline and the amikacin is (6400: 1)-(12800: 1). The FIC index of the Chinese pulsatilla root decoction combined with the ceftriaxone, the amikacin or the tetracycline for use is 0.1875-0.375 and is less than 0.5, that is, the Chinese pulsatilla root decoction combined with the ceftriaxone, the amikacin or the tetracycline for use has a synergistic antibacterial effect. The dosage of ceftriaxone, amikacin or tetracycline can be effectively reduced, the MIC value of the Chinese pulsatilla decoction combined with ceftriaxone, amikacin or tetracycline is 2-16 times lower than that of the Chinese pulsatilla decoction independently used, the Chinese pulsatilla decoction can be used as an anti-drug re