Anti-glycan-LAMP1 antibodies and uses thereof

The present disclosure relates to antiglycan-LAMP1 antibodies and antigen binding fragments thereof and related fusion proteins and antibody-drug conjugates that specifically bind to cancer specific glycosylated variants of LAMP1, as well as nucleic acids encoding such biomolecules. The disclosure further relates to the use of the antibodies, antigen-binding fragments, fusion proteins, antibody-drug conjugates and nucleic acids for the treatment of cancer. 本公开涉及特异性结合LAMP1的癌症特异性糖基化变体的抗糖-LAMP1抗体及其抗原结合片段和相关的融合蛋白和抗体-药物缀合物，以及编码此类生物分子的核酸。本公开进一步涉及抗体、抗原结合片段、融合蛋白、抗体-药物缀合物和核酸用于癌症治疗的用途。