Compositions comprising 2 '-deoxycytidine analogs and their use for treatment of sickle cell disease, thalassemia and cancer

In one aspect, the present disclosure relates to pharmaceutical compositions comprising 2 '-deoxycytidine analogs, oral and other dose formulations comprising the same, and methods of making the same. In another aspect, the present disclosure relates to methods of using them to treat hematological conditions and diseases associated with abnormal cell proliferation. In another aspect, the present disclosure relates to kits comprising 2 '-deoxycytidine analogs that are useful in the treatment of hematological conditions and diseases associated with abnormal cell proliferation. In another aspect, the present disclosure relates to methods for increasing fetal hemoglobin levels in a subject. This abstract is intended as a search tool for purposes of retrieval in the particular art and is not intended to be limiting of the present disclosure. 在一个方面中，本公开内容涉及包含2'-脱氧胞苷类似物的药物组合物、包含其的经口和其他剂量制剂，以及其制备方法。在另一个方面中，本公开内容涉及使用它们来治疗与异常细胞增殖相关的血液学病症和疾病的方法。在另一个方面中，本公开内容涉及包含2'-脱氧胞苷类似物的药盒，其可用于治疗与异常细胞增殖相关的血液学病症和疾病。在另一个方面中，本公开内容涉及用于在对象