Combined marker for diagnosing early bladder cancer

The invention discloses a combined marker for diagnosing early bladder cancer, and the marker is combined with ceramide Cer, 2-amino-4, 6-piperidinediol, phosphatidyl ethanolamine PE, 1-methylguanine, melibiose, 6-O-methylguanine, carnitine C12: 1-OH, carnitine C10: 2, (R)-3-hydroxymyristic acid and...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: WANG FUBO, WU FAN, ZHOU RONGBIN, WEI CHUNMENG, MO ZENGNAN, WANG ZUHENG, LI XIAO, ZHANG HUIYONG, LEE SOO-YOUNG, HE HAIMEI, LU WENHAO
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention discloses a combined marker for diagnosing early bladder cancer, and the marker is combined with ceramide Cer, 2-amino-4, 6-piperidinediol, phosphatidyl ethanolamine PE, 1-methylguanine, melibiose, 6-O-methylguanine, carnitine C12: 1-OH, carnitine C10: 2, (R)-3-hydroxymyristic acid and 3-hydroxytetradecanoic acid, so that diagnosis indexes of the early bladder cancer can be established. The bladder cancer is diagnosed. According to the method, variable screening and dimensionality reduction are carried out through minimum absolute convergence and selection operators, the early diagnosis model of the bladder cancer is constructed by utilizing logistic regression analysis, and the diagnosis effectiveness AUC of a marker diagnosis combination reaches 0.999. And in almost all threshold ranges, the benefit obtained by using the constructed model to diagnose a patient is higher than that obtained by using an extreme curve. Compared with previous reports, the kit is excellent in early diagnosis effect,