Combined marker for diagnosing early bladder cancer
The invention discloses a combined marker for diagnosing early bladder cancer, and the marker is combined with ceramide Cer, 2-amino-4, 6-piperidinediol, phosphatidyl ethanolamine PE, 1-methylguanine, melibiose, 6-O-methylguanine, carnitine C12: 1-OH, carnitine C10: 2, (R)-3-hydroxymyristic acid and...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a combined marker for diagnosing early bladder cancer, and the marker is combined with ceramide Cer, 2-amino-4, 6-piperidinediol, phosphatidyl ethanolamine PE, 1-methylguanine, melibiose, 6-O-methylguanine, carnitine C12: 1-OH, carnitine C10: 2, (R)-3-hydroxymyristic acid and 3-hydroxytetradecanoic acid, so that diagnosis indexes of the early bladder cancer can be established. The bladder cancer is diagnosed. According to the method, variable screening and dimensionality reduction are carried out through minimum absolute convergence and selection operators, the early diagnosis model of the bladder cancer is constructed by utilizing logistic regression analysis, and the diagnosis effectiveness AUC of a marker diagnosis combination reaches 0.999. And in almost all threshold ranges, the benefit obtained by using the constructed model to diagnose a patient is higher than that obtained by using an extreme curve. Compared with previous reports, the kit is excellent in early diagnosis effect, |
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