Anti-fibrosis cyclic peptide and application thereof

The invention discloses an anti-fibrosis cyclic peptide and application thereof. By constructing an in-vitro cell model of hepatic fibrosis, it is found that the polypeptide T2 generated by degradation of basement membrane glycan can reduce the expression quantity of I-type collagen in the model and has a certain anti-fibrosis effect. On the basis of the polypeptide T2, a series of cyclic peptides with the anti-fibrosis effect superior to that of the polypeptide T2 are obtained through different cyclization strategies, and the polypeptide T2 or the cyclic peptides can be used for preparing anti-fibrosis drugs. According to the invention, the source of effective components for preparing the anti-fibrosis medicine is enriched, and the treatment of fibrosis diseases such as hepatic fibrosis and the like is facilitated. 本发明公开了一种抗纤维化的环肽及其应用。本发明通过构建肝纤维化的体外细胞模型发现，由基膜聚糖降解产生的多肽T2可以降低模型中I型胶原蛋白的表达量，具有一定的抗纤维化效果。在所述多肽T2的基础上，本发明通过不同的环化策略，获得了抗纤维化效果优于多肽T2的一系列环肽，可将所述多肽T2或所述环肽用于制备抗纤维化的药物。本发明丰富了可用于制备抗纤维化药物的有效成分来源，有利于肝纤维化等纤维化疾病的