Inhibitor targeting RIPK1 kinase and application thereof
The invention discloses an inhibitor targeting RIPK1 kinase and application of the inhibitor. The inhibitor targeting RIPK1 kinase is selected from a compound with a structure shown as a general formula (I) or (II) or pharmaceutically acceptable salt of the compound. The invention provides a series...
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| creator | CUI NINGJIE KONG LINGYI WANG XIAOBING |
| description | The invention discloses an inhibitor targeting RIPK1 kinase and application of the inhibitor. The inhibitor targeting RIPK1 kinase is selected from a compound with a structure shown as a general formula (I) or (II) or pharmaceutically acceptable salt of the compound. The invention provides a series of novel kinase targeted inhibitors, and the compound disclosed by the invention can effectively target RIPK1 kinase and can be used as an effective therapeutic agent for inflammation-related diseases.
本发明公开了一类靶向RIPK1激酶的抑制剂及其应用，所述的靶向RIPK1激酶的抑制剂选自结构如通式(Ⅰ)或(II)所示的化合物或其药学上可接受的盐。本发明提供了一系列新型的激酶靶向抑制剂，本发明所公示化合物能够有效的靶向RIPK1激酶，可作为炎症相关疾病的有效治疗剂。 |
| format | Patent |
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本发明公开了一类靶向RIPK1激酶的抑制剂及其应用，所述的靶向RIPK1激酶的抑制剂选自结构如通式(Ⅰ)或(II)所示的化合物或其药学上可接受的盐。本发明提供了一系列新型的激酶靶向抑制剂，本发明所公示化合物能够有效的靶向RIPK1激酶，可作为炎症相关疾病的有效治疗剂。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240716&DB=EPODOC&CC=CN&NR=118344359A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240716&DB=EPODOC&CC=CN&NR=118344359A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CUI NINGJIE</creatorcontrib><creatorcontrib>KONG LINGYI</creatorcontrib><creatorcontrib>WANG XIAOBING</creatorcontrib><title>Inhibitor targeting RIPK1 kinase and application thereof</title><description>The invention discloses an inhibitor targeting RIPK1 kinase and application of the inhibitor. The inhibitor targeting RIPK1 kinase is selected from a compound with a structure shown as a general formula (I) or (II) or pharmaceutically acceptable salt of the compound. The invention provides a series of novel kinase targeted inhibitors, and the compound disclosed by the invention can effectively target RIPK1 kinase and can be used as an effective therapeutic agent for inflammation-related diseases.
本发明公开了一类靶向RIPK1激酶的抑制剂及其应用，所述的靶向RIPK1激酶的抑制剂选自结构如通式(Ⅰ)或(II)所示的化合物或其药学上可接受的盐。本发明提供了一系列新型的激酶靶向抑制剂，本发明所公示化合物能够有效的靶向RIPK1激酶，可作为炎症相关疾病的有效治疗剂。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDwzMvITMosyS9SKEksSk8tycxLVwjyDPA2VMjOzEssTlVIzEtRSCwoyMlMTizJzM9TKMlILUrNT-NhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoaGFsYmJsamlo7GxKgBANgELe4</recordid><startdate>20240716</startdate><enddate>20240716</enddate><creator>CUI NINGJIE</creator><creator>KONG LINGYI</creator><creator>WANG XIAOBING</creator><scope>EVB</scope></search><sort><creationdate>20240716</creationdate><title>Inhibitor targeting RIPK1 kinase and application thereof</title><author>CUI NINGJIE ; KONG LINGYI ; WANG XIAOBING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118344359A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CUI NINGJIE</creatorcontrib><creatorcontrib>KONG LINGYI</creatorcontrib><creatorcontrib>WANG XIAOBING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CUI NINGJIE</au><au>KONG LINGYI</au><au>WANG XIAOBING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Inhibitor targeting RIPK1 kinase and application thereof</title><date>2024-07-16</date><risdate>2024</risdate><abstract>The invention discloses an inhibitor targeting RIPK1 kinase and application of the inhibitor. The inhibitor targeting RIPK1 kinase is selected from a compound with a structure shown as a general formula (I) or (II) or pharmaceutically acceptable salt of the compound. The invention provides a series of novel kinase targeted inhibitors, and the compound disclosed by the invention can effectively target RIPK1 kinase and can be used as an effective therapeutic agent for inflammation-related diseases.
本发明公开了一类靶向RIPK1激酶的抑制剂及其应用，所述的靶向RIPK1激酶的抑制剂选自结构如通式(Ⅰ)或(II)所示的化合物或其药学上可接受的盐。本发明提供了一系列新型的激酶靶向抑制剂，本发明所公示化合物能够有效的靶向RIPK1激酶，可作为炎症相关疾病的有效治疗剂。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Inhibitor targeting RIPK1 kinase and application thereof |
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