Compound with benzamide structure as well as preparation method and application of compound

The invention discloses a compound with a benzamide structure as shown in a formula (I), a preparation method of the compound, and application of the compound in preparation of a pharmaceutical preparation for preventing or treating diseases caused by CRBN abnormality. The compound in the formula (I) is a small molecule compound with CRBN covalent binding inhibition activity. The diseases are tumors, including mantle cell lymphoma, multiple myeloma, non-Hodgkin lymphoma and solid tumors, or autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis and psoriasis. # imgabs0 # 本发明公开了如式(I)所示具有苯甲酰胺结构的化合物，以及该化合物的制备方法，以及在制备预防或治疗因CRBN异常所引起的疾病的药物制剂中在应用。式(I)化合物为具有CRBN共价结合抑制活性的小分子化合物。所述的疾病为为肿瘤，包括套细胞淋巴瘤、多发性骨髓瘤、非霍奇金淋巴瘤、实体瘤，或者为自体免疫疾病，包括类风湿关节炎、系统性红斑狼疮、强直性脊柱炎、银屑病。#imgabs0#