20-deoxycinol ether derivative with anti-tumor activity as well as preparation and application of 20-deoxycinol ether derivative

The invention discloses a 20-deoxyingenol ether derivative with anti-tumor activity as well as preparation and application thereof, belongs to the field of medicinal chemistry, relates to a preparation method and application of a diterpene ether derivative, and particularly relates to application of an ether derivative of Ingenane diterpene in the anti-tumor aspect. The invention provides an ether derivative of 20-deoxyingenol with antitumor activity. The derivative has a chemical structure as shown in a formula (I), a formula (II), a formula (III), a formula (IV) or a formula (V), the invention also provides a preparation method of the derivative. The derivative has good tumor inhibition activity, and has very high potential research value and clinical application prospect. # imgabs0 # 本发明公开一种具有抗肿瘤活性的20-deoxyingenol醚衍生物及其制备与应用，属于药物化学领域，涉及二萜醚衍生物的制备方法和应用，具体涉及Ingenane二萜的醚衍生物在抗肿瘤方面的应用。本发明提供了具有抗肿瘤活性的20-deoxyingenol的醚衍生物，所述衍生物具有式(I)、式(II)、式(III)、式(IV)或式(V)所示的化学结构；本发明还提供了该衍生物的制备方法。该衍生物具有良好的肿瘤抑制活性，具有非常高的潜在研究价值和临床应用前