Antisense oligonucleotides for modulating HTRA1 expression

The present invention relates to antisense oligonucleotides (oligomers) that are complementary to HTRA1, which result in modulation of HTRA1 expression. Modulation of HTRA1 expression is beneficial to a range of medical conditions, such as macular degeneration, such as age-related macular degenerati...

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Bibliographische Detailangaben
Hauptverfasser:	IARCONI, ROBERTO, TROSTASSEN, SINDRE, HUDLEBUSCH HEIDI, KEMMLER, SUSANNE, HAJDORN, PETER, OTTOSSON, SU REN, PEDERSEN LYKKE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to antisense oligonucleotides (oligomers) that are complementary to HTRA1, which result in modulation of HTRA1 expression. Modulation of HTRA1 expression is beneficial to a range of medical conditions, such as macular degeneration, such as age-related macular degeneration. 本发明涉及与HTRA1互补的反义寡核苷酸(寡聚体)，其导致HTRA1表达的调节。HTRA1表达的调节有益于一系列医学病症，如黄斑变性，例如年龄相关性黄斑变性。