SOLID FORMS COMPRISING OXOISOINDOLE COMPOUNDS AND SALTS THEREOF, AND COMPOSITIONS COMPRISING SAME AND METHODS OF THEIR USE

SOLID FORMS COMPRISING OXOISOINDOLE COMPOUNDS AND SALTS THEREOF, AND COMPOSITIONS COMPRISING SAME AND METHODS OF THEIR USE

Provided herein are formulations, processes, solid forms, and methods of use that relate to salts of (S)-4-(4-(((2-(2, 6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl) oxy) methyl) benzyl) piperazin-1-yl)-3-fluorobenzonitrile and compositions comprising (S)-4-(4-(((2-(2, 6-dioxopiperidin-3-yl)-1-oxoisoi...

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Bibliographische Detailangaben
Hauptverfasser: FERRETTI ANTONIO C, HUANG LIANFENG, WU WENJU, ARTMAN III GERALD D, YIN ZHIWEI, TAVARES-GRECO PAULA A, ZOU NANCY NIEHUA, JAIN, UDAY KUMAR, MAN HON-WAH
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided herein are formulations, processes, solid forms, and methods of use that relate to salts of (S)-4-(4-(((2-(2, 6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl) oxy) methyl) benzyl) piperazin-1-yl)-3-fluorobenzonitrile and compositions comprising (S)-4-(4-(((2-(2, 6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl) methyl) piperazin-1-yl)-3-fluorobenzonitrile and salts of (S)-4-(4-(((2-(2, 6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)-3-fluorobenzonitrile. The present invention relates to a solid form of a free base or salt of 2, 6-dioxopiperidine-3-yl)-1-oxoisoindolin-4-yl) oxy) methyl) benzyl) piperazin-1-yl)-3-fluorobenzonitrile. 本文提供了配方、工艺、固体形式和使用方法，它们涉及(S)-4-(4-(4-(((2-(2，6-二氧代哌啶-3-基)-1-氧代异吲哚啉-4-基)氧基)甲基)苯甲基)哌嗪-1-基)-3-氟苯甲腈的盐以及包含(S)-4-(4-(4-(((2-(2，6-二氧代哌啶-3-基)-1-氧代异吲哚啉-4-基)氧基)甲基)苯甲基)哌嗪-1-基)-3-氟苯甲腈的游离碱或盐的固体形式。