Indolines as PROTAC compounds

The present invention relates to compounds of formula (I) which target the DNA mismatch repair (MMR) component PMS2 wherein R2, R4, R6, A1, A2, A4, L and Q are each as defined herein. The invention also relates to processes for preparing these compounds, pharmaceutical compositions comprising them,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	BRAGG JULIAN, CLARK DAVID, DRYSDALE, MARTIN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention relates to compounds of formula (I) which target the DNA mismatch repair (MMR) component PMS2 wherein R2, R4, R6, A1, A2, A4, L and Q are each as defined herein. The invention also relates to processes for preparing these compounds, pharmaceutical compositions comprising them, and their use in the treatment of proliferative diseases in which PMS2 is involved, such as cancer and other diseases or conditions. # imgabs0 # 本发明涉及式(I)的化合物，其靶向DNA错配修复(MMR)组分PMS2，其中R2、R4、R6、A1、A2、A4、L和Q各自如本文所定义。本发明还涉及制备这些化合物的方法，包含它们的药物组合物，以及它们在治疗其中涉及PMS2的增殖性疾病如癌症以及其他疾病或病况中的用途。#imgabs0#