Biomarker for diagnosing ovarian cancer, primer pair, nucleic acid product, kit and application

The invention discloses a biomarker for diagnosing ovarian cancer, a primer pair, a nucleic acid product, a kit and application. The marker comprises a full-length or partial region of a positive chain of Chr10: 93567151-93567551 of a GPR120 gene and/or a full-length or partial region of a negative chain of Chr18: 3499055-3499455 of a DLGAP1 (Digital Ligand Growth Amplification Protein 1) gene. Ovarian cancer patients and healthy people can be distinguished by detecting the methylation level of the marker in the sample. The invention further discloses a primer pair, a probe, a kit and other products for detecting the marker, and the products can effectively detect the methylation level of the marker in a tissue or blood sample, so that the sensitivity and specificity of early diagnosis are improved while non-invasive detection of the ovarian cancer is realized. 本申请公开了用于诊断卵巢癌的生物标志物、引物对、核酸产品、试剂盒及应用。该标志物包括GPR120基因的Chr10:93567151-93567551正链的全长或部分区域和/或DLGAP1基因的Chr18:3499055-3499455负链的全长或部分区域。通过检测样本中标志物的甲基化水平，能够区分卵