Isoalantolactone compound as well as preparation method and application thereof

The invention discloses an isoalantolactone compound as well as a preparation method and application thereof, the isoalantolactone compound has a structure as shown in a formula I: # imgabs0 #. The isoalantolactone compound provided by the invention has a very strong inhibition effect on histone deacetylase, has a very strong inhibition effect on cancer cells, and has a very strong inhibition effect on cancer cells. A new generation of anticancer lead compound can be formed; compared with the marketed histone deacetylase inhibitor vorinostat, the isoalantolactone compound provided by the invention has the advantages that the activity of histone deacetylase is obviously improved, the effect on solid tumors such as lung cancer is better, and the problems that the activity of the existing histone deacetylase inhibitor is lower, the curative effect on the solid tumors is poorer and the like are solved. 本发明公开了一种异土木香内酯类化合物及其制备方法和应用，其具有式Ⅰ所示的结构：#imgabs0#本发明的所提供的异土木香内酯类化合物对组蛋白去乙酰化酶具有很强的抑制作用，对癌细胞具有很强的抑制作用，可形成新一代的抗癌先导化合