Synthesis method of 2-phenylbenzyl-2-dimethylamino-1-(4-morpholinobenzylphenyl) butanone

The invention discloses a synthesis method of 2-phenylbenzyl-2-dimethylamino-1-(4-morpholinobenzylphenyl) butanone, and belongs to the field of preparation of photoinitiators. The method specifically comprises the following steps: (1) reacting chlorobenzene with morpholine to prepare N-phenylmorpholine; (2) N-phenylmorpholine and 2-aminobutyric acid are subjected to a Friedel-Crafts reaction, and a compound I is prepared; (3) carrying out an aminomethylation reaction on the compound I, formic acid and formaldehyde to prepare a compound II; and (4) reacting the compound II with benzyl chloride to obtain the 2-phenylbenzyl-2-dimethylamino-1-(4-morpholinobenzylphenyl) butanone. By implementing the method, the process route can be simplified, the use of fluorobenzene, bromine and the like is avoided, and the yield is increased. 本发明公开了一种2-苯基苄-2-二甲基胺-1-(4-吗啉苄苯基)丁酮的合成方法，属于光引发剂制备领域。其具体包括以下步骤：(1)氯苯与吗啉反应制得N-苯基吗啉；(2)N-苯基吗啉与2-氨基丁酸经傅-克反应，制得化合物Ⅰ；(3)化合物Ⅰ与甲酸、甲醛进行氨甲基化反应，制得化合物Ⅱ；(4)化合物Ⅱ与氯苄反应，得到2-苯基苄-2-二甲基胺-1-(4-吗啉苄苯基)丁酮。实施本发明，可