PH-responsive acid-sensitive micelle as well as preparation method and application thereof

The invention discloses a pH-responsive acid-sensitive micelle as well as a preparation method and application thereof, and particularly relates to the technical field of medicines. The preparation method of the pH responsive acid-sensitive micelle comprises the following steps: firstly, preparing mPEG-beta-CD, then, preparing 0831 A-Hyd-AD, and finally, preparing the 0831 A-Hyd-AD/mPEG n-beta-CD micelle. The micelle is an acid-sensitive polymer micelle drug delivery system based on an acylhydrazone bond, and is a tumor microenvironment acid-responsive PEGylated nano-micelle. A 0831A-Hyd-AD and mPEG-beta-CD assembled micelle is synthesized and prepared by utilizing the non-covalent binding effect between CD and adamantane, 0831A and adamantane are bonded through an acylhydrazone bond, tumor microenvironment response is formed, and meanwhile, the in-vivo stability of the micelle can be improved through non-covalent binding between cyclodextrin and adamantane. 本发明公开了一种pH响应性酸敏感胶束及其制备方法和应用，具体涉及医药技术领域。pH响应性酸敏感胶束是通