Coronavirus vaccine

The present disclosure relates to the field of RNAs for the prevention or treatment of coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccinating against coronavirus infection and inducing an effective coronavirus antigen-specific immune response, such as an antibody and/or T cell response. Specifically, in an embodiment, the disclosure relates to a method comprising administering to a subject an RNA encoding a peptide or protein comprising an SARS-CoV-2 spike protein (S protein) epitope for inducing an immune response (i.e., a vaccine RNA encoding a vaccine antigen) against a coronavirus S protein, particularly an S protein of SARS-CoV-2, in a subject. 本公开涉及预防或治疗冠状病毒感染的RNA的领域。特别地，本公开涉及用于针对冠状病毒感染进行疫苗接种并诱导有效的冠状病毒抗原特异性免疫应答如抗体和/或T细胞应答的方法和药剂。具体地，在一实施方案中，本公开涉及这样的方法，其包括向受试者给药RNA，所述RNA编码包含SARS-CoV-2刺突蛋白(S蛋白)表位的肽或蛋白，用于在受试者中诱导针对冠状病毒S蛋白(特别是SARS-CoV-2的S蛋白)的免疫应答(即编码疫苗抗原的疫苗RNA)。