Polypeptide for improving skin injury or aging and application thereof

The invention provides a polypeptide PEP-SKP for improving skin injury or aging. The amino acid sequence of the polypeptide is as shown in SEQ ID NO: 1. The polypeptide PEP-SKP provided by the invention aims at a Granzyme B protein target spot, shows a good effect in an in-vivo and in-vitro experime...

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Bibliographische Detailangaben
Hauptverfasser:	SHI SONGCHUAN, ZHAO SHUMIN, CAMPBELL WILLIAM, LIAO WENQIANG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides a polypeptide PEP-SKP for improving skin injury or aging. The amino acid sequence of the polypeptide is as shown in SEQ ID NO: 1. The polypeptide PEP-SKP provided by the invention aims at a Granzyme B protein target spot, shows a good effect in an in-vivo and in-vitro experiment for inhibiting Granzyme B, and can be used for preparing a medicine with an effect of improving skin injury or aging. 本申请提供一种改善皮肤损伤或衰老的多肽PEP-SKP，所述多肽的氨基酸序列如SEQ ID NO：1所示。本申请所述多肽PEP-SKP针对Granzyme B蛋白靶点，在抑制Granzyme B的体内体外实验中显示良好的效果，可用于制备治疗具有改善皮肤损伤或衰老作用的药物。