Method for decarboxylating and halogenating 2-pyridone derivative

The invention belongs to the technical field of organic synthesis, and relates to a decarboxylation halogenation method of a 2-pyridone derivative. The invention provides a decarboxylation halogenation method of a 2-pyridone derivative, which comprises the following steps: dissolving a compound 1 in a reaction solvent, adding a catalyst, stirring at 25-30 DEG C until the system is clear, adding a halogenation reagent, and reacting to obtain a compound 2. According to the method, the lithium salt catalyst and the low-toxicity solvent are used, explosive and highly toxic reagents are not used, the reaction condition is mild and controllable, the reaction speed is high, and industrial production can be achieved easily. 本发明属于有机合成技术领域，涉及一种2-吡啶酮衍生物的脱羧卤代方法。本发明提供了一种2-吡啶酮衍生物的脱羧卤代方法，将化合物1溶于反应溶剂中，加入催化剂，在25℃～30℃下搅拌至体系澄清后，加入卤代试剂，反应得到化合物2。本发明的方法通过使用锂盐催化剂，低毒溶剂，未使用易爆、剧毒试剂，反应条件温和可控，反应速度快，有利于实现工业化生产。