Application of trapidil in preparation of medicine for treating diabetic cardiomyopathy

The invention relates to the field of biological medicines, in particular to application of trapidil in preparation of a medicine for treating diabetic cardiomyopathy. The new application of the traditional Chinese medicine trapidil is found, and the trapidil can improve apoptosis, hypertrophy and f...

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Bibliographische Detailangaben
Hauptverfasser: WANG YUCHUN, LIU JICHENG, WANG YUTING, SUN YINGZI, WANG ZIHAO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the field of biological medicines, in particular to application of trapidil in preparation of a medicine for treating diabetic cardiomyopathy. The new application of the traditional Chinese medicine trapidil is found, and the trapidil can improve apoptosis, hypertrophy and fibrosis of myocardial cells of the diabetic cardiomyopathy, so that the cardiac function is improved, symptoms are relieved, the effect of treating the diabetic cardiomyopathy is achieved, and the life quality of a patient can be improved. The new effect of the trapidil on inhibiting the diabetic cardiomyopathy is found for the first time, and experimental results show that the trapidil can significantly inhibit myocardial cell apoptosis, myocardial hypertrophy and fibrosis of diabetic cardiomyopathy in-vivo and in-vitro models, can significantly inhibit myocardial tissue/myocardial cell p-NF-kB and p-JNK protein expression and ROS generation, and can up-regulate S100A1 protein; the expression of cardiac muscle tis