Super dc expressing immune checkpoint inhibitors and uses thereof

Provided are antigen presenting cells that secrete a PD-1 binding molecule and/or a CTLA-4 binding molecule or contain a coding sequence thereof. The antigen presenting cell can activate immature T cells and effectively stimulate the effector function of the activated T cells on cancers. 提供了分泌PD-1结合...

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Bibliographische Detailangaben
Hauptverfasser:	QIAN QIJUN, ADWISH, MONAND, WU ZEJI, SHI CHUANYIN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided are antigen presenting cells that secrete a PD-1 binding molecule and/or a CTLA-4 binding molecule or contain a coding sequence thereof. The antigen presenting cell can activate immature T cells and effectively stimulate the effector function of the activated T cells on cancers. 提供了分泌PD-1结合分子和/或CTLA-4结合分子或含有其编码序列的抗原呈递细胞。该抗原呈递细胞可以激活幼稚T细胞活化，有效刺激激活的T细胞对癌症的效应功能。