Construction method and application of conjunctival relaxation animal model

The invention discloses a construction method and application of a conjunctival relaxation animal model. The construction method of the conjunctival relaxation animal model comprises the following steps: performing D-galactose high-dose subcutaneous injection on a New Zealand rabbit; the injection amount of the D-galactose is 50 mg/kg. A D-galactose high-dose subcutaneous injection animal model constructed by the invention is most similar to bulbar conjunctiva representation, OCT bulbar conjunctiva thickness representation, tear cytokines and histopathologic change of a CCH patient, and inflammatory response and senescence induced by D-galactose are important pathogenesis of the CCH. Therefore, the model can be used as an effective and reliable animal model for conjunctival relaxation and can be further applied to pathogenesis research of the conjunctival relaxation. 本发明公开了一种结膜松弛症动物模型的构建方法及其应用，该结膜松弛症动物模型的构建方法包括如下步骤：将新西兰兔进行D-半乳糖高剂量皮下注射；D-半乳糖的注射量为50mg/kg。本发明构建的D-半乳糖高剂量皮下注射的动物模型与CCH患者的球结膜表征、OCT球结膜厚度表现、泪液细胞因子及组织病