Urine micron vesicle miRNA marker and application thereof, and kit for diagnosing secondary glomerular disease

The invention relates to the technical field of molecular diagnosis, and discloses a urine micron vesicle miRNA marker, application thereof and a kit for diagnosing secondary glomerular diseases. The urine micro vesicle miRNA marker is selected from at least one of the following components: hsa-miR-21-5p, hsa-miR-205-5p, hsa-miR-135b-5p, hsa-miR-203a-3p, hsa-miR-223-5p, hsa-miR-1338-5p, and hsa-miR-514a-3p, and the urine micro vesicle miRNA marker is used for detecting the urine micro vesicle miRNA. The urine micron vesicle miRNA marker provided by the invention can stably exist in urine for a long time, is resistant to RNA enzyme degradation, can be used for early diagnosis, individualized treatment and prognosis of lupus nephritis, and provides possibility for use of novel biological agents. 本发明涉及分子诊断技术领域，公开了一种尿液微米囊泡miRNA标志物及其应用、诊断继发性肾小球疾病的试剂盒。该尿液微米囊泡miRNA标志物选自hsa-miR-21-5p、hsa-miR-205-5p、hsa-miR-135b-5p、hsa-miR-203a-3p、hsa-miR-223-5p、hsa-miR-138-5p、hsa-miR-514a-3p中的至少一种。本发明提供的尿液微米囊泡miRNA标志物可以长期稳定存在尿液中，耐RNA