Recombinant protein of norovirus P particle chimeric LcR7 protein as well as preparation method and application of recombinant protein

The invention provides a recombinant protein of norovirus P particle chimeric LcR7 protein as well as a preparation method and application of the recombinant protein, the recombinant protein comprises a norovirus P structural domain and LcR7 protein, the amino acid sequence of the norovirus P struct...

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Bibliographische Detailangaben
Hauptverfasser:	TAN ZHIJIAN, LIU LIDAN, WANG XINQIU, KUANG CHUNMAN, LIN RUIQING, WENG YABIAO, SHANG ZHIXIANG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides a recombinant protein of norovirus P particle chimeric LcR7 protein as well as a preparation method and application of the recombinant protein, the recombinant protein comprises a norovirus P structural domain and LcR7 protein, the amino acid sequence of the norovirus P structural domain is as shown in SEQ ID No.3, and the amino acid sequence of the LcR7 protein is as shown in SEQ ID No.4. The recombinant protein of the norovirus P particle chimeric LcR7 protein can be used as the LcR7 vaccine for preventing and treating animal LcR7, can maintain a high antibody level for a long time, and provides a new method for prevention and control of LcR7. 本发明提供了一种诺如病毒P颗粒嵌合嵌合LcR7蛋白的重组蛋白及其制备方法和用途，所述重组蛋白包含诺如病毒P结构域和卡氏住白细胞虫R7蛋白，所述诺如病毒P结构域的氨基酸序列如SEQ ID No.3所示，所述卡氏住白细胞虫R7蛋白的氨基酸序列如SEQ ID No.4所示。诺如病毒P颗粒嵌合嵌合LcR7蛋白的重组蛋白可作为卡氏住白细胞虫病疫苗用于防治动物卡氏住白细胞虫病，能维持长时间高抗体水平，为卡氏住白细胞虫病的防控提供新的方法。