Fusion protein of conopeptide and preparation method of conopeptide

The invention provides a conopeptide fusion protein, a biological material and a conopeptide preparation method. Wherein the fusion protein of conopeptide comprises conopeptide and foreign protein, and the foreign protein is selected from leader peptide or thioredoxin. According to the application, a genetic engineering technology is used, an appropriate fusion expression tag is selected to construct an engineering bacterium capable of recombining and expressing the anti-wrinkle conopeptide, and the required anti-wrinkle conopeptide product can be obtained through fermentation, separation and purification of the engineering bacterium. The method provided by the invention not only can efficiently express the anti-wrinkle conopeptide product, but also can solve the defects of a chemical synthesis method, and is an efficient and cheap anti-wrinkle conopeptide preparation process. 本申请提供一种芋螺肽的融合蛋白、生物材料及芋螺肽的制备方法。其中，所述芋螺肽的融合蛋白包含芋螺肽和外源蛋白，所述外源蛋白选自前导肽或硫氧还蛋白。本申请使用基因工程的技术，选择合适的融合表达标签构建了可重组表达抗皱芋螺肽的工程菌，通过工程菌发酵、分离纯化即可得到所需的抗