Recombinant human collagen as well as preparation method and application thereof

The invention belongs to the technical field of protein engineering and genetic engineering, and particularly relates to recombinant human collagen as well as a preparation method and application thereof. The recombinant human collagen is constructed and expressed by adopting a gene recombination te...

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Bibliographische Detailangaben
Hauptverfasser:	GAO XIUYAN, ZHENG HONGXIA
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ENZYMOLOGY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS SPIRITS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention belongs to the technical field of protein engineering and genetic engineering, and particularly relates to recombinant human collagen as well as a preparation method and application thereof. The recombinant human collagen is constructed and expressed by adopting a gene recombination technology and taking a human III type collagen gene sequence as a template, and the recombinant collagen contains a human III type collagen sequence and has high biocompatibility and high activity. Compared with natural collagen, the collagen has the advantages of hydrophilicity, water solubility and high expression quantity. Tests prove that the recombinant humanized collagen constructed by the invention has the effects of quickly stopping bleeding and promoting damaged tissue repair, can be used as a raw material of medical instruments, and is very suitable for industrial large-scale production by utilizing a prokaryotic fermentation protein expression system, so that the recombinant humanized collagen has a good