Alfacalcidol soft capsule and preparation method thereof

The invention belongs to the technical field of medicament preparation, and particularly relates to an alfacalcidol soft capsule and a preparation method thereof. The alfacalcidol soft capsule consists of a soft capsule shell and a soft capsule content, the soft capsule shell is prepared from the following raw materials: 60 to 100 parts of modified hydroxypropyl methylcellulose-starch matrix, 10 to 20 parts of citrate, 1 to 3 parts of nano zinc oxide and 100 to 150 parts of water; the soft capsule content is prepared from the following raw materials in parts by weight: 0.001 to 0.005 part of alfacalcidol, 500 to 800 parts of medium chain triglyceride, 1 to 5 parts of glyceryl monostearate, 0.5 to 2 parts of stabilizer and 5 to 10 parts of emulsifier. The alfacalcidol is prevented from being in contact with oxygen and water by adopting the modified hydroxypropyl methylcellulose and the starch shell. The drug is wrapped in glyceryl monostearate by using an ultrasonic emulsification technology, so that the chemi